Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise.
Document identifier: oai:dalea.du.se:2327
Publication year: 1999Relevant Sustainable Development Goals (SDGs):
The SDG label(s) above have been assigned by OSDG.aiAbstract: The aim of the present study was to investigate the concentration of ubiquinone-10 (Q10), at rest, in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementation. Another aim was to explore whether adenine nucleotide catabolism, lipid peroxidation, and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or a Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. There was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in either group. Plasma hypoxanthine and uric acid concentrations increased markedly after each exercise test session in both groups. After the training period, the postexercise increase in plasma hypoxanthine was markedly reduced in both groups, but the response was partially reversed after the recovery period. It was concluded that Q10 supplementation increases the concentration of Q10 in plasma but not in skeletal muscle.
Authors
Michael Svensson
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Christer Malm
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Michail Tonkonogi
Högskolan Dalarna; Medicinsk vetenskap
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Björn Ekblom
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Bertil Sjödin
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Kent Sahlin
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identifier: oai:dalea.du.se:2327
datestamp: 2021-04-15T12:24:05Z
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titleInfo:
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lang: eng
title: Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise.
abstract: The aim of the present study was to investigate the concentration of ubiquinone-10 (Q10) at rest in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementation. Another aim was to explore whether adenine nucleotide catabolism lipid peroxidation and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or a Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. There was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in either group. Plasma hypoxanthine and uric acid concentrations increased markedly after each exercise test session in both groups. After the training period the postexercise increase in plasma hypoxanthine was markedly reduced in both groups but the response was partially reversed after the recovery period. It was concluded that Q10 supplementation increases the concentration of Q10 in plasma but not in skeletal muscle.
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languageTerm: eng
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publication/journal-article
ref
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Published
6
name:
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Svensson
Michael
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Malm
Christer
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Tonkonogi
Michail
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Högskolan Dalarna
Medicinsk vetenskap
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0000-0003-1619-9758
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Ekblom
Björn
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Sjödin
Bertil
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Sahlin
Kent
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roleTerm: aut
originInfo:
dateIssued: 1999
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titleInfo:
title: Int J Sport Nutr
identifier: 1526-484X
part:
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type: volume
number: 9
extent:
start: 166
end: 180
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form: print
typeOfResource: text