Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise.

Document identifier: oai:dalea.du.se:2327
Publication year: 1999
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Abstract:

The aim of the present study was to investigate the concentration of ubiquinone-10 (Q10), at rest, in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementation. Another aim was to explore whether adenine nucleotide catabolism, lipid peroxidation, and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or a Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. There was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in either group. Plasma hypoxanthine and uric acid concentrations increased markedly after each exercise test session in both groups. After the training period, the postexercise increase in plasma hypoxanthine was markedly reduced in both groups, but the response was partially reversed after the recovery period. It was concluded that Q10 supplementation increases the concentration of Q10 in plasma but not in skeletal muscle.

Authors

Michael Svensson

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Christer Malm

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Michail Tonkonogi

Högskolan Dalarna; Medicinsk vetenskap
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Björn Ekblom

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Bertil Sjödin

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Kent Sahlin

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    header: 
        identifier: oai:dalea.du.se:2327
        datestamp: 2021-04-15T12:24:05Z
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                version: 3.7
            recordInfo: 
                recordContentSource: du
                recordCreationDate: 2006-10-02
            identifier: http://urn.kb.se/resolve?urn=urn:nbn:se:du-2327
            titleInfo: 
                @attributes: 
                    lang: eng
                title: Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise.
            abstract: 
The aim of the present study was to investigate the concentration of ubiquinone-10 (Q10) at rest in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementation. Another aim was to explore whether adenine nucleotide catabolism lipid peroxidation and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or a Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. There was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in either group. Plasma hypoxanthine and uric acid concentrations increased markedly after each exercise test session in both groups. After the training period the postexercise increase in plasma hypoxanthine was markedly reduced in both groups but the response was partially reversed after the recovery period. It was concluded that Q10 supplementation increases the concentration of Q10 in plasma but not in skeletal muscle.

            language: 
                languageTerm: eng
            genre: 
                publication/journal-article
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                Published
                6
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                        type: personal
                    namePart: 
                        Svensson
                        Michael
                    role: 
                        roleTerm: aut
                    @attributes: 
                        type: personal
                    namePart: 
                        Malm
                        Christer
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                        roleTerm: aut
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                        type: personal
                        authority: du
                    namePart: 
                        Tonkonogi
                        Michail
                    role: 
                        roleTerm: aut
                    affiliation: 
                        Högskolan Dalarna
                        Medicinsk vetenskap
                    nameIdentifier: 
                        mtn
                        0000-0003-1619-9758
                    @attributes: 
                        type: personal
                    namePart: 
                        Ekblom
                        Björn
                    role: 
                        roleTerm: aut
                    @attributes: 
                        type: personal
                    namePart: 
                        Sjödin
                        Bertil
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                        roleTerm: aut
                    @attributes: 
                        type: personal
                    namePart: 
                        Sahlin
                        Kent
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            originInfo: 
                dateIssued: 1999
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                titleInfo: 
                    title: Int J Sport Nutr
                identifier: 1526-484X 
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                    detail: 
                        @attributes: 
                            type: volume
                        number: 9
                    extent: 
                        start: 166
                        end: 180
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