Outcome prediction of enteral levodopa/carbidopa infusion in advanced Parkinson's disease

Document identifier: oai:dalea.du.se:1905
Access full text here:10.1016/j.parkreldis.2006.02.006
Keyword: Medical and Health Sciences, Clinical Medicine, Medicin och hälsovetenskap, Klinisk medicin, Natural Sciences, Computer and Information Sciences, Naturvetenskap, Data- och informationsvetenskap, Outcome prediction, Predictive model, Predictive factor Parkinson, Continous dopaminergic stimulation, Improvement measure, Infusion, Levodopa
Publication year: 2006
Relevant Sustainable Development Goals (SDGs):
SDG 3 Good health and wellbeing
The SDG label(s) above have been assigned by OSDG.ai

Abstract:

Two studies comparing intraduodenal infusion of a levodopa/carbidopa gel with oral treatments in advanced PD patients, demonstrated improvement in UPDRS scores and in frequent clinical ratings on a global treatment response scale. Further analysis of data from these studies was performed to find predictive factors related to degree of improvement with infusion. Pearson correlation coefficients between measures of improvement and baseline variables were calculated. Using data from one study, a prediction model was designed and was then evaluated using the other study’s data. Correlations were found indicating that patients with more severe symptoms at baseline were most improved after infusion.

Authors

Jerker Westin

Högskolan Dalarna; Datateknik
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Dag Nyholm

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Torgny Groth

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Mark Dougherty

Högskolan Dalarna; Datateknik
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Praveen Yerramsetty

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Sven Pålhagen

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