Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau

implications for future treatment recommendations

Document identifier: oai:dalea.du.se:1620
Keyword: Engineering and Technology, Chemical Engineering, Teknik och teknologier, Kemiteknik, Medical and Health Sciences, Clinical Medicine, Medicin och hälsovetenskap, Klinisk medicin, Malaria; Plasmodium falciparum; Drug therapy; Chloroquine; Amodiaquine; West Africa
Publication year: 2007
Relevant Sustainable Development Goals (SDGs):
SDG 3 Good health and wellbeing
The SDG label(s) above have been assigned by OSDG.ai

Abstract:

The aim of the present study was to compare different doses of chloroquine (CQ) and amodiaquine (AQ) for the treatment of falciparum malaria in children. Children with Plasmodium falciparum monoinfection were allocated by block randomisation to treatment with CQ 50/kg mg or 25 mg/kg or AQ 15 mg/kg or 30 mg/kg. The main outcomes were the cumulative adequate clinical and parasitological response (ACPR) rates and the number of true recrudescences as determined by PCR. A total of 729 children were included. In an evaluability analysis, the PCR-uncorrected cumulative ACPR rates on Day 28 for the treatment groups CQ 50/kg mg or 25 mg/kg and AQ 15 mg/kg or 30 mg/kg were 90%, 76%, 92% and 94%, respectively; the PCR-adjusted ACPR rates on Day 28 were 92%, 80%, 94% and 94%, respectively. No differences in adverse effects were observed. AQ has a high cure rate given as 30 mg/kg and 15 mg/kg, although it is not superior to treatment with CQ 50 mg/kg. However, 25 mg/kg of CQ is less efficient. As an interim option, Guinea-Bissau could change the recommended first-line treatment of uncomplicated malaria to CQ 50 mg/kg, reserving AQ as a partner drug for a future combination therapy.

Authors

P.E. Kofoed

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J. Ursing

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A. Poulsen

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A. Rodrigues

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Yngve Bergqvist

Högskolan Dalarna; Kemiteknik
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P. Aaby

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L. Rombo

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