A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma
Document identifier: oai:dalea.du.se:1619
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10.1016/j.jpba.2005.10.018Keyword: Natural Sciences,
Chemical Sciences,
Naturvetenskap,
Kemi,
Antimalarial; amoditiquine; chloroquine; desethylamodiaquine; liquid chromatography; solid-phase extraction; stabilityPublication year: 2006Abstract: A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ, AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds, of which at least one is already known to be stable, permits a within sample ratio to be used as a stability indicator, The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days, at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days, at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.
Authors
Daniel Blessborn
Högskolan Dalarna; Kemiteknik
Other publications
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G. Neamin
Other publications
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Yngve Bergqvist
Högskolan Dalarna; Kemiteknik
Other publications
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N. Lindegårdh
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header:
identifier: oai:dalea.du.se:1619
datestamp: 2021-04-15T12:55:26Z
setSpec: SwePub-du
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recordContentSource: du
recordCreationDate: 2005-12-21
identifier:
http://urn.kb.se/resolve?urn=urn:nbn:se:du-1619
10.1016/j.jpba.2005.10.018
16307860
titleInfo:
@attributes:
lang: eng
title: A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma
abstract: A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds of which at least one is already known to be stable permits a within sample ratio to be used as a stability indicator The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.
subject:
@attributes:
lang: eng
authority: uka.se
topic:
Natural Sciences
Chemical Sciences
@attributes:
lang: swe
authority: uka.se
topic:
Naturvetenskap
Kemi
@attributes:
lang: eng
topic: antimalarial; amoditiquine; chloroquine; desethylamodiaquine; liquid chromatography; solid-phase extraction; stability
language:
languageTerm: eng
genre:
publication/journal-article
ref
note:
Published
4
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Blessborn
Daniel
role:
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affiliation:
Högskolan Dalarna
Kemiteknik
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namePart:
Neamin
G.
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roleTerm: aut
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Bergqvist
Yngve
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Högskolan Dalarna
Kemiteknik
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Lindegårdh
N.
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originInfo:
dateIssued: 2006
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title: Journal of Pharmaceutical and Biomedical Analysis
identifier:
0731-7085
1873-264X
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type: volume
number: 41
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number: 1
extent:
start: 207
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