A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma

Document identifier: oai:dalea.du.se:1619
Access full text here:10.1016/j.jpba.2005.10.018
Keyword: Natural Sciences, Chemical Sciences, Naturvetenskap, Kemi, Antimalarial; amoditiquine; chloroquine; desethylamodiaquine; liquid chromatography; solid-phase extraction; stability
Publication year: 2006
Abstract:

A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ, AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds, of which at least one is already known to be stable, permits a within sample ratio to be used as a stability indicator, The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days, at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days, at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.

Authors

Daniel Blessborn

Högskolan Dalarna; Kemiteknik
Other publications >>

G. Neamin

Other publications >>

Yngve Bergqvist

Högskolan Dalarna; Kemiteknik
Other publications >>

N. Lindegårdh

Other publications >>

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    header: 
        identifier: oai:dalea.du.se:1619
        datestamp: 2021-04-15T12:55:26Z
        setSpec: SwePub-du
    metadata: 
        mods: 
            @attributes: 
                version: 3.7
            recordInfo: 
                recordContentSource: du
                recordCreationDate: 2005-12-21
            identifier: 
                http://urn.kb.se/resolve?urn=urn:nbn:se:du-1619
                10.1016/j.jpba.2005.10.018
                16307860
            titleInfo: 
                @attributes: 
                    lang: eng
                title: A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma
            abstract: 
A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds of which at least one is already known to be stable permits a within sample ratio to be used as a stability indicator The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.

            subject: 
                    @attributes: 
                        lang: eng
                        authority: uka.se
                    topic: 
                        Natural Sciences
                        Chemical Sciences
                    @attributes: 
                        lang: swe
                        authority: uka.se
                    topic: 
                        Naturvetenskap
                        Kemi
                    @attributes: 
                        lang: eng
                    topic: antimalarial; amoditiquine; chloroquine; desethylamodiaquine; liquid chromatography; solid-phase extraction; stability
            language: 
                languageTerm: eng
            genre: 
                publication/journal-article
                ref
            note: 
                Published
                4
            name: 
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                        type: personal
                        authority: du
                    namePart: 
                        Blessborn
                        Daniel
                    role: 
                        roleTerm: aut
                    affiliation: 
                        Högskolan Dalarna
                        Kemiteknik
                    nameIdentifier: dbl
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                        type: personal
                    namePart: 
                        Neamin
                        G.
                    role: 
                        roleTerm: aut
                    @attributes: 
                        type: personal
                        authority: du
                    namePart: 
                        Bergqvist
                        Yngve
                    role: 
                        roleTerm: aut
                    affiliation: 
                        Högskolan Dalarna
                        Kemiteknik
                    nameIdentifier: ybq
                    @attributes: 
                        type: personal
                    namePart: 
                        Lindegårdh
                        N.
                    role: 
                        roleTerm: aut
            originInfo: 
                dateIssued: 2006
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                titleInfo: 
                    title: Journal of Pharmaceutical and Biomedical Analysis
                identifier: 
                    0731-7085
                    1873-264X
                part: 
                    detail: 
                            @attributes: 
                                type: volume
                            number: 41
                            @attributes: 
                                type: issue
                            number: 1
                    extent: 
                        start: 207
                        end: 212
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            typeOfResource: text