Engineering electroactive and biocompatible tetra(aniline)-based terpolymers with tunable intrinsic antioxidant properties in vivo
Document identifier: oai:DiVA.org:ltu-76829
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10.1016/j.msec.2019.110456Keyword: Natural Sciences,
Chemical Sciences,
Physical Chemistry,
Naturvetenskap,
Kemi,
Fysikalisk kemi,
Tetra(aniline),
Electroactive terpolymers,
Thermal stability,
Antioxidant,
Biocompatible,
Diabetes,
Chemistry of Interfaces,
Gränsytors kemiPublication year: 2020Relevant Sustainable Development Goals (SDGs):
The SDG label(s) above have been assigned by OSDG.aiAbstract: Under different pathological conditions, high levels of reactive oxygen species (ROS) cause substantial damage to multiple organs. To counter these ROS levels in multiple organs, we have engineered highly potent novel terpolymers. We found that combination of FDA-approved polyethylene glycol, fumaric acid moieties and electroactive tetra(aniline) by varying the content of tetra(aniline) results into a novel drug composition with biologically active tunable intrinsic antioxidant properties. To test tunable intrinsic antioxidative properties of these engineered novel terpolymers, we used alloxan to induce diabetes in rats where ROS generation is known to be higher. The systemic administration of terpolymers to the diabetic rats showed strong electroactive antioxidant behavior which normalized ROS levels, enzymatic antioxidants including superoxide dismutase, catalase, but also reduced glutathione. As a proof-of-principle, we here show TANI based novel drug composition of terpolymers with tunable intrinsic antioxidant effects confirmed in multiple organs.
Authors
Irrum Mushtaq
Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Iram Mushtaq
Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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>>
Zareen Akhter
Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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>>
Iram Murtaza
Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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>>
Samina Qamar
Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Sidra Ayub
Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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>>
Bushra Mirza
Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Tehmeena Maryum Butt
Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Naveed Kausar Janjua
Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Faiz Ullah Shah
Luleå tekniska universitet; Kemiteknik
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Farasat Zaman
Department of Women's and Children's Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Solna, Sweden
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header:
identifier: oai:DiVA.org:ltu-76829
datestamp: 2021-04-19T12:42:05Z
setSpec: SwePub-ltu
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recordContentSource: ltu
recordCreationDate: 2019-11-23
identifier:
http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-76829
10.1016/j.msec.2019.110456
31924021
2-s2.0-85075739838
titleInfo:
@attributes:
lang: eng
title: Engineering electroactive and biocompatible tetra(aniline)-based terpolymers with tunable intrinsic antioxidant properties in vivo
abstract: Under different pathological conditions high levels of reactive oxygen species (ROS) cause substantial damage to multiple organs. To counter these ROS levels in multiple organs we have engineered highly potent novel terpolymers. We found that combination of FDA-approved polyethylene glycol fumaric acid moieties and electroactive tetra(aniline) by varying the content of tetra(aniline) results into a novel drug composition with biologically active tunable intrinsic antioxidant properties. To test tunable intrinsic antioxidative properties of these engineered novel terpolymers we used alloxan to induce diabetes in rats where ROS generation is known to be higher. The systemic administration of terpolymers to the diabetic rats showed strong electroactive antioxidant behavior which normalized ROS levels enzymatic antioxidants including superoxide dismutase catalase but also reduced glutathione. As a proof-of-principle we here show TANI based novel drug composition of terpolymers with tunable intrinsic antioxidant effects confirmed in multiple organs.
subject:
@attributes:
lang: eng
authority: uka.se
topic:
Natural Sciences
Chemical Sciences
Physical Chemistry
@attributes:
lang: swe
authority: uka.se
topic:
Naturvetenskap
Kemi
Fysikalisk kemi
@attributes:
lang: eng
topic: Tetra(aniline)
@attributes:
lang: eng
topic: Electroactive terpolymers
@attributes:
lang: eng
topic: Thermal stability
@attributes:
lang: eng
topic: Antioxidant
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lang: eng
topic: Biocompatible
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lang: eng
topic: Diabetes
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lang: eng
authority: ltu
topic: Chemistry of Interfaces
genre: Research subject
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lang: swe
authority: ltu
topic: Gränsytors kemi
genre: Research subject
language:
languageTerm: eng
genre:
publication/journal-article
ref
note:
Published
11
Validerad;2019;Nivå 2;2019-12-09 (johcin)
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Mushtaq
Irrum
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affiliation: Department of Chemistry Quaid-i-Azam University Islamabad Pakistan
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Mushtaq
Iram
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affiliation: Department of Biochemistry Quaid-i-Azam University Islamabad Pakistan
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Akhter
Zareen
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affiliation: Department of Chemistry Quaid-i-Azam University Islamabad Pakistan
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Murtaza
Iram
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affiliation: Department of Biochemistry Quaid-i-Azam University Islamabad Pakistan
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Qamar
Samina
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affiliation: Department of Chemistry Quaid-i-Azam University Islamabad Pakistan
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Ayub
Sidra
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affiliation: Department of Biochemistry Quaid-i-Azam University Islamabad Pakistan
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Mirza
Bushra
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affiliation: Department of Biochemistry Quaid-i-Azam University Islamabad Pakistan
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Butt
Tehmeena Maryum
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affiliation: Department of Chemistry Quaid-i-Azam University Islamabad Pakistan
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Janjua
Naveed Kausar
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affiliation: Department of Chemistry Quaid-i-Azam University Islamabad Pakistan
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authority: ltu
namePart:
Shah
Faiz Ullah
1981-
role:
roleTerm: aut
affiliation:
Luleå tekniska universitet
Kemiteknik
nameIdentifier:
faisha
0000-0003-3652-7798
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namePart:
Zaman
Farasat
role:
roleTerm: aut
affiliation: Department of Women's and Children's Health Karolinska Institutet and Pediatric Endocrinology Unit Karolinska University Hospital Solna Sweden
originInfo:
dateIssued: 2020
publisher: Elsevier
relatedItem:
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type: host
titleInfo:
title: Materials science & engineering. C biomimetic materials sensors and systems
identifier:
0928-4931
1873-0191
part:
detail:
@attributes:
type: volume
number: 108
@attributes:
type: artNo
number: 110456
physicalDescription:
form: print
typeOfResource: text