Engineering electroactive and biocompatible tetra(aniline)-based terpolymers with tunable intrinsic antioxidant properties in vivo

Document identifier: oai:DiVA.org:ltu-76829
Access full text here:10.1016/j.msec.2019.110456
Keyword: Natural Sciences, Chemical Sciences, Physical Chemistry, Naturvetenskap, Kemi, Fysikalisk kemi, Tetra(aniline), Electroactive terpolymers, Thermal stability, Antioxidant, Biocompatible, Diabetes, Chemistry of Interfaces, Gränsytors kemi
Publication year: 2020
Relevant Sustainable Development Goals (SDGs):
SDG 3 Good health and wellbeing
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Abstract:

Under different pathological conditions, high levels of reactive oxygen species (ROS) cause substantial damage to multiple organs. To counter these ROS levels in multiple organs, we have engineered highly potent novel terpolymers. We found that combination of FDA-approved polyethylene glycol, fumaric acid moieties and electroactive tetra(aniline) by varying the content of tetra(aniline) results into a novel drug composition with biologically active tunable intrinsic antioxidant properties. To test tunable intrinsic antioxidative properties of these engineered novel terpolymers, we used alloxan to induce diabetes in rats where ROS generation is known to be higher. The systemic administration of terpolymers to the diabetic rats showed strong electroactive antioxidant behavior which normalized ROS levels, enzymatic antioxidants including superoxide dismutase, catalase, but also reduced glutathione. As a proof-of-principle, we here show TANI based novel drug composition of terpolymers with tunable intrinsic antioxidant effects confirmed in multiple organs.

Authors

Irrum Mushtaq

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Iram Mushtaq

Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Zareen Akhter

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Iram Murtaza

Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Samina Qamar

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Sidra Ayub

Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Bushra Mirza

Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Tehmeena Maryum Butt

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Naveed Kausar Janjua

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
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Faiz Ullah Shah

Luleå tekniska universitet; Kemiteknik
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Farasat Zaman

Department of Women's and Children's Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Solna, Sweden
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