A Molecular Communications Model for Drug Delivery
Document identifier: oai:DiVA.org:ltu-7658
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10.1109/TNB.2015.2489565Keyword: Natural Sciences,
Computer and Information Sciences,
Media and Communication Technology,
Naturvetenskap,
Data- och informationsvetenskap,
Medieteknik,
Mobile and Pervasive Computing,
Distribuerade datorsystemPublication year: 2015Relevant Sustainable Development Goals (SDGs):
The SDG label(s) above have been assigned by OSDG.aiAbstract: This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g., a tumor), able to deliver drug molecules in the diseased area. Suitably located transmitters are designed to release a continuous flow of drug molecules in the surrounding environment, where they diffuse and reach the target. These molecules are received when they chemically react with compliant receptors deployed on the receiver surface. In these conditions, if the release rate is relatively high and the drug absorption time is significant, congestion may happen, essentially at the receiver site. This phenomenon limits the drug absorption rate and makes the signal transmission ineffective, with an undesired diffusion of drug molecules elsewhere in the body. The original contribution of this paper consists of a theoretical analysis of the causes of congestion in diffusion-based molecular communications. For this purpose, it is proposed a reception model consisting of a set of pure loss queuing systems. The proposed model exhibits an excellent agreement with the results of a simulation campaign made by using the Biological and Nano-Scale communication simulator version 2 (BiNS2), a well-known simulator for molecular communications, whose reliability has been assessed through in vitro experiments. The obtained results can be used in rate control algorithms to optimally determine the optimal release rate of molecules in drug delivery applications
Authors
Marco Femminella
Department of Engineering, University of Perugia CNIT RU
Other publications
>>
Gianluca Reali
Department of Engineering, University of Perugia CNIT RU
Other publications
>>
Athanasios Vasilakos
Luleå tekniska universitet; Datavetenskap
Other publications
>>
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header:
identifier: oai:DiVA.org:ltu-7658
datestamp: 2021-04-19T12:21:25Z
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titleInfo:
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lang: eng
title: A Molecular Communications Model for Drug Delivery
abstract: This paper considers the scenario of a targeted drug delivery system which consists of deploying a number of biological nanomachines close to a biological target (e.g. a tumor) able to deliver drug molecules in the diseased area. Suitably located transmitters are designed to release a continuous flow of drug molecules in the surrounding environment where they diffuse and reach the target. These molecules are received when they chemically react with compliant receptors deployed on the receiver surface. In these conditions if the release rate is relatively high and the drug absorption time is significant congestion may happen essentially at the receiver site. This phenomenon limits the drug absorption rate and makes the signal transmission ineffective with an undesired diffusion of drug molecules elsewhere in the body. The original contribution of this paper consists of a theoretical analysis of the causes of congestion in diffusion-based molecular communications. For this purpose it is proposed a reception model consisting of a set of pure loss queuing systems. The proposed model exhibits an excellent agreement with the results of a simulation campaign made by using the Biological and Nano-Scale communication simulator version 2 (BiNS2) a well-known simulator for molecular communications whose reliability has been assessed through in vitro experiments. The obtained results can be used in rate control algorithms to optimally determine the optimal release rate of molecules in drug delivery applications
subject:
@attributes:
lang: eng
authority: uka.se
topic:
Natural Sciences
Computer and Information Sciences
Media and Communication Technology
@attributes:
lang: swe
authority: uka.se
topic:
Naturvetenskap
Data- och informationsvetenskap
Medieteknik
@attributes:
lang: eng
authority: ltu
topic: Mobile and Pervasive Computing
genre: Research subject
@attributes:
lang: swe
authority: ltu
topic: Distribuerade datorsystem
genre: Research subject
language:
languageTerm: eng
genre:
publication/journal-article
ref
note:
Published
3
Validerad; 2016; Nivå 2; 20160219 (andbra)
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Femminella
Marco
role:
roleTerm: aut
affiliation: Department of Engineering University of Perugia CNIT RU
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Reali
Gianluca
role:
roleTerm: aut
affiliation: Department of Engineering University of Perugia CNIT RU
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authority: ltu
namePart:
Vasilakos
Athanasios
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affiliation:
Luleå tekniska universitet
Datavetenskap
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thanos
0000-0003-1902-9877
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dateIssued: 2015
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type: host
titleInfo:
title: IEEE Transactions on Nanobioscience
identifier:
1536-1241
1558-2639
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type: volume
number: 14
@attributes:
type: issue
number: 8
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