Formation of cocrystals from stoichiometric solutions of incongruently saturating systems by spray drying

Document identifier: oai:DiVA.org:ltu-7596
Access full text here:10.1021/cg100451q
Keyword: Medical and Health Sciences, Health Sciences, Other Health Sciences, Medicin och hälsovetenskap, Hälsovetenskaper, Annan hälsovetenskap, Health Science, Hälsovetenskap
Publication year: 2010
Abstract:

Spray drying is a well established technique for material processing and scale-up. This study investigated the formation of pharmaceutical cocrystals by spray drying. The cocrystal formation mechanisms in spray-drying and solution methods, based on triangular phase diagrams, are discussed. The solvent evaporation of stoichiometric solutions of incongruently saturating cocrystals resulted in a mixture of phases, as dictated by the thermodynamic phase diagram. In contrast, spray drying of similar solutions of incongruently saturating systems generated pure cocrystals. It is thus suggested that the formation of cocrystals by spray drying could be kinetically controlled and/or mediated by the glassy state of the material.

Authors

Amjad Alhalaweh

Luleå tekniska universitet; Medicinsk vetenskap
Other publications >>

Sitaram Velaga

Luleå tekniska universitet; Medicinsk vetenskap
Other publications >>

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    header: 
        identifier: oai:DiVA.org:ltu-7596
        datestamp: 2021-04-19T12:21:46Z
        setSpec: SwePub-ltu
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                version: 3.7
            recordInfo: 
                recordContentSource: ltu
                recordCreationDate: 2016-09-29
            identifier: 
                http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-7596
                10.1021/cg100451q
                2-s2.0-77955338170
                5fb42e60-a6cb-11df-a707-000ea68e967b
            titleInfo: 
                @attributes: 
                    lang: eng
                title: Formation of cocrystals from stoichiometric solutions of incongruently saturating systems by spray drying
            abstract: 
Spray drying is a well established technique for material processing and  scale-up. This study investigated the formation of pharmaceutical cocrystals by  spray drying. The cocrystal formation mechanisms in spray-drying and solution  methods based on triangular phase diagrams are discussed. The solvent  evaporation of stoichiometric solutions of incongruently saturating cocrystals  resulted in a mixture of phases as dictated by the thermodynamic phase diagram.  In contrast spray drying of similar solutions of incongruently saturating  systems generated pure cocrystals. It is thus suggested that the formation of  cocrystals by spray drying could be kinetically controlled and/or mediated by  the glassy state of the material.

            subject: 
                    @attributes: 
                        lang: eng
                        authority: uka.se
                    topic: 
                        Medical and Health Sciences
                        Health Sciences
                        Other Health Sciences
                    @attributes: 
                        lang: swe
                        authority: uka.se
                    topic: 
                        Medicin och hälsovetenskap
                        Hälsovetenskaper
                        Annan hälsovetenskap
                    @attributes: 
                        lang: eng
                        authority: ltu
                    topic: Health Science
                    genre: Research subject
                    @attributes: 
                        lang: swe
                        authority: ltu
                    topic: Hälsovetenskap
                    genre: Research subject
            language: 
                languageTerm: eng
            genre: 
                publication/journal-article
                ref
            note: 
                Published
                2
                Validerad; 2010; 20100813 (ysko)
            name: 
                    @attributes: 
                        type: personal
                        authority: ltu
                    namePart: 
                        Alhalaweh
                        Amjad
                    role: 
                        roleTerm: aut
                    affiliation: 
                        Luleå tekniska universitet
                        Medicinsk vetenskap
                    nameIdentifier: 
                        amjalh
                        0000-0002-6050-0432
                    @attributes: 
                        type: personal
                        authority: ltu
                    namePart: 
                        Velaga
                        Sitaram
                    role: 
                        roleTerm: aut
                    affiliation: 
                        Luleå tekniska universitet
                        Medicinsk vetenskap
                    nameIdentifier: 
                        sitvel
                        0000-0002-0654-5410
            originInfo: 
                dateIssued: 2010
            relatedItem: 
                @attributes: 
                    type: host
                titleInfo: 
                    title: Crystal Growth & Design
                identifier: 
                    1528-7483
                    1528-7505
                part: 
                    detail: 
                            @attributes: 
                                type: volume
                            number: 10
                            @attributes: 
                                type: issue
                            number: 8
                    extent: 
                        start: 3302
                        end: 3305
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            typeOfResource: text