Spectroscopic monitoring of environmentally benign anti-solvent crystallization

Document identifier: oai:DiVA.org:ltu-7586
Access full text here:10.1016/0022-0248(95)00920-5
Keyword: Engineering and Technology, Industrial Biotechnology, Bioprocess Technology, Teknik och teknologier, Industriell bioteknik, Bioprocessteknik, Biokemisk processteknik, Biochemical Process Engineering
Publication year: 1996
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Abstract:

There are very few studies dealing with the fundamentals of anti-solvent crystallization, even though this crystallization method is widely used in the pharmaceutical industry. Anti-solvent crystallization is accomplished by adding a miscible anti-solvent into a mixture of solute and solvent, effectively reducing the solubility of the solute in the solvent, and thus, causing the crystallization of the solute. Unfortunately, many of the anti-solvents used today are chlorinated hydrocarbons suspected of environmental damage. The current research demonstrates the use of environmentally benign solvents for anti-solvent crystallization and new approaches for monitoring of the solvent behavior during an anti-solvent crystallization. Results are presented confirming the efficacy of various water and ester systems for anti-solvent crystallization. Furthermore, the application of fluorescence spectroscopy for monitoring these crystallizations is demonstrated.

Authors

Marketta S Uusi-Penttilä

Michigan State University
Other publications >>

Kris Berglund

Other publications >>

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        identifier: oai:DiVA.org:ltu-7586
        datestamp: 2021-04-19T11:02:29Z
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                version: 3.7
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                recordContentSource: ltu
                recordCreationDate: 2016-09-29
            identifier: 
                http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-7586
                10.1016/0022-0248(95)00920-5
                5f8aaa20-3bc6-11de-a8ec-000ea68e967b
            titleInfo: 
                @attributes: 
                    lang: eng
                title: Spectroscopic monitoring of environmentally benign anti-solvent crystallization
            abstract: 
There are very few studies dealing with the fundamentals of anti-solvent crystallization even though this crystallization method is widely used in the pharmaceutical industry. Anti-solvent crystallization is accomplished by adding a miscible anti-solvent into a mixture of solute and solvent effectively reducing the solubility of the solute in the solvent and thus causing the crystallization of the solute. Unfortunately many of the anti-solvents used today are chlorinated hydrocarbons suspected of environmental damage. The current research demonstrates the use of environmentally benign solvents for anti-solvent crystallization and new approaches for monitoring of the solvent behavior during an anti-solvent crystallization. Results are presented confirming the efficacy of various water and ester systems for anti-solvent crystallization. Furthermore the application of fluorescence spectroscopy for monitoring these crystallizations is demonstrated.

            subject: 
                    @attributes: 
                        lang: eng
                        authority: uka.se
                    topic: 
                        Engineering and Technology
                        Industrial Biotechnology
                        Bioprocess Technology
                    @attributes: 
                        lang: swe
                        authority: uka.se
                    topic: 
                        Teknik och teknologier
                        Industriell bioteknik
                        Bioprocessteknik
                    @attributes: 
                        lang: swe
                        authority: ltu
                    topic: Biokemisk processteknik
                    genre: Research subject
                    @attributes: 
                        lang: eng
                        authority: ltu
                    topic: Biochemical Process Engineering
                    genre: Research subject
            language: 
                languageTerm: eng
            genre: 
                publication/journal-article
                ref
            note: 
                Published
                2
                Upprättat; 1996; 20090508 (ysko)
            name: 
                    @attributes: 
                        type: personal
                    namePart: 
                        Uusi-Penttilä
                        Marketta S
                    role: 
                        roleTerm: aut
                    affiliation: Michigan State University
                    @attributes: 
                        type: personal
                        authority: ltu
                    namePart: 
                        Berglund
                        Kris
                    role: 
                        roleTerm: aut
                    nameIdentifier: krib
            originInfo: 
                dateIssued: 1996
            relatedItem: 
                @attributes: 
                    type: host
                titleInfo: 
                    title: Journal of Crystal Growth
                identifier: 
                    0022-0248
                    1873-5002
                part: 
                    detail: 
                            @attributes: 
                                type: volume
                            number: 166
                            @attributes: 
                                type: issue
                            number: 1-4
                    extent: 
                        start: 967
                        end: 970
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                form: print
            typeOfResource: text